FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation
نویسندگان
چکیده
منابع مشابه
Ras activity regulates cyclin E degradation by the Fbw7 pathway.
The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis. Fbw7 is a human tumor suppressor that is targeted for mutation in primary cancers. However, mechanisms other than mutation of Fbw7 may also disrupt cyclin E proteolysis in cancers. We show that onc...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2013
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2013.42